
CKD PROGRESSION IN T2D:
AN EVOLVING UNDERSTANDING OF THE DAMAGE BEING DONE
3 MAJOR DRIVERS OF CKD PROGRESSION IN PATIENTS WITH T2D1-4

Metabolic Drivers
- Elevated HbA1c

Hemodynamic Drivers
- Elevated BP
- High intraglomerular pressure

Inflammatory
and Fibrotic Drivers
- Presence and/or release of proinflammatory proteins and profibrotic proteins
CKD Progression
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BP: blood pressure; CKD: chronic kidney disease; HbA1c: glycated hemoglobin; KDIGO: Kidney Disease Improving Global Outcomes; T2D: type 2 diabetes.
References:
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- Alicic RZ, et al. Clin J Am Soc Nephrol. 2017;12(12):2032–2045.
- Black LM, et al. J Histochem Cytochem. 2019;67(9):663–681.
- Tesch GH, et al. Front Pharmacol. 2017;8. doi:10.3389/fphar.2017.00313.
- Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int Suppl. 2013;3(1):1–150.
- Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. Kidney Int. 2020;98(4S):S1–S115.
- American Diabetes Association. Diabetes Care. 2021;44(suppl 1):S1–S232.
- Duckworth W, et al; VADT Investigators. N Engl J Med. 2009;360(2):129–139.
- The ACCORD Study Group. N Engl J Med. 2010;362(17):1575–1585.