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CKD progression in T2D destroys kidneys



Disrupt the current thinking about chronic kidney disease (CKD) progression in type 2 diabetes (T2D)

Even with HbA1c and blood pressure under control, CKD patients with T2D still face kidney damage due to inflammation and fibrosis, a largely unaddressed and major cause of CKD progression.1-3

3 drivers include inflammation and fibrosis

Inflammation and fibrosis is one of 3 main drivers of CKD progression1

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Watch video about what drives CKD progression

Watch how inflammation and fibrosis are triggered by mineralocorticoid receptor overactivation4

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Unaddressed inflammation and fibrosis in CKD patients with T2D can lead to CKD progression, end-stage kidney disease, and increased cardiovascular risk.1,3,4

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  • Alicic RZ, Rooney MT, Tuttle KR. Clin J Am Soc Nephrol. 2017;12(12):2032-2045.
  • Brenner BM, Cooper ME, De Zeeuw D, et al. N Engl J Med. 2001;345(12):861-869.
  • Perkovic V, Jardine MJ, Neal B, et al. N Engl J Med. 2019;380(24):2295-2306.
  • Bauersachs J, Jaisser F, Toto R. Hypertension. 2015;65(2):257-263.