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Drivers of progression

DRIVERS OF PROGRESSION

CKD PROGRESSION IN T2D IS INFLUENCED BY
3 MAJOR DRIVERS1,2

Metabolic driver of CKD

Metabolic Drivers

  • Elevated blood glucose (A1c) levels
Hemodynamic driver of CKD

Hemodynamic Drivers

  • Elevated blood pressure (BP)
  • High intraglomerular pressure
Inflammatory and fibrotic drivers

Inflammatory and Fibrotic Drivers

  • Presence and/or release of proinflammatory cytokines and fibrotic proteins

Chronic kidney disease (CKD) progression

CKD: chronic kidney disease; T2D: type 2 diabetes.

Inflammatory and fibrotic drivers in the kidneys are largely unaddressed in patients with CKD in T2D1

A1c AND BP CONTROL AREN’T ALWAYS ENOUGH3-5

Today, physicians are fighting CKD in T2D on multiple fronts. But even with well-controlled A1c and blood pressure (BP), many patients with CKD in T2D are still experiencing CKD progression. While modest gains have been made due to advancements in the field, there are more opportunities to reduce the residual risk of4-7:

  • End-stage kidney disease (ESKD)
  • Death from renal disease
CKD Progression Image

Even when controlling BP with the current standard of care, CKD progression continues6

Intensive-a1c image

Intensive A1c control has only a modest impact on ESKD progression4,5

Learn more about Inflammation and fibrosis

Learn more about inflammation and fibrosis

Learn More
Watch video about what drives CKD progression

Watch how inflammation and fibrosis are triggered

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References:

  • Alicic RZ, Rooney MT, Tuttle KR. Clin J Am Soc Nephrol. 2017;12(12):2032–2045.
  • Bauersachs J, Jaisser F, Toto R. Hypertension. 2015;65(2):257-263.
  • ACCORD Study Group, Cushman WC, Evans GW, et al. N Engl J Med. 2010;362(17):1575-1585.
  • Duckworth W, Abraira C, Moritz T, et al. N Engl J Med. 2009;360(2):129-139.
  • Ismail-Beigi F, Craven T, Banerji MA, et al. Lancet. 2010;376(9739):419-430.
  • Brenner BM, Cooper ME, De Zeeuw D, et al. N Engl J Med. 2001;345(12):861-869.
  • Thomas MC, Brownlee M, Susztak K, et al. Nat Rev Dis Primers. 2015;1:15018.