This site is intended for US healthcare professionals

MEASURING KIDNEY DAMAGE

DETECTING KIDNEY DAMAGE

Luiza Caramori, MD, PhD, MSc, explores the kidney damage and CKD progression that can result from inflammation and fibrosis

ALBUMINURIA: AN EARLY SIGNAL OF KIDNEY DAMAGE AND CKD PROGRESSION1,2

INFLAMMATION AND FIBROSIS CAN CAUSE ALBUMINURIA, WHICH IS AN EARLY DETECTABLE MARKER OF KIDNEY DAMAGE1-3

kidney damage UACR testing icon

UACR testing is used to detect kidney damage by measuring the ratio of albumin to creatinine in the urine1

kidney damage UACR rising icon

Rising UACR levels are an indicator of worsening kidney damage and a predictor of CKD progression1

eGFR TESTING ALONE MAY MISS EARLY SIGNS OF KIDNEY DAMAGE1,2,4

UACR eGFR testing icon

Even patients with eGFR >60 mL/min/1.73 m2 may be at increased risk of CKD progression if albuminuria is present1,5

UACR eGFR detecting icon

UACR can detect kidney damage even when patients' eGFR is >60 mL/min5,6

WHEN LEFT LARGELY UNADDRESSED, INFLAMMATION AND FIBROSIS MAY CAUSE IRREVOCABLE KIDNEY DAMAGE7-9

Thank you for visiting our site. The questions you'll see throughout are completely voluntary. If you choose to answer the questions, you'll gain access to our video library and other resources.

Thank you for your response

Be the first to hear the latest developments in CKD and T2D, and unlock videos from experts like Dr. Rajiv Agarwal

Sign up

CKD: chronic kidney disease; eGFR: estimated glomerular filtration rate; T2D: type 2 diabetes; UACR: urine albumin-to-creatinine ratio.

References:

  • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int Suppl. 2013;3(1):1–150.
  • Campion CG, et al. Can J Kidney Health Dis. 2017;4. doi:10.1177/2054358117705371.
  • Thomas MC, et al. Nat Rev Dis Primers. 2015;1. doi:10.1038/nrdp.2015.18.
  • American Diabetes Association. Diabetes Care. 2021;44(suppl 1):S1–S232.
  • Levey AS, et al. Kidney Int. 2011;80(1):17-28.
  • Kidney Failure Risk Factor: Urine Albumin-to-Creatinine Ration (UACR). National Kidney Foundation. Accessed February 18, 2021. https://www.kidney.org/content/kidney-failure-risk-factor-urine-albumin-to-creatinine-ration-uacr.
  • Tesch GH, et al. Front Pharmacol. 2017;8. doi:10.3389/fphar.2017.00313.
  • Alicic RZ, et al. Clin J Am Soc Nephrol. 2017;12(12):2032–2045.
  • Black LM, et al. J Histochem Cytochem. 2019;67(9):663–681.