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Luiza Caramori, MD, PhD, MSc, explains the role of MR overactivation in inflammation and fibrosis

Inflammation and fibrosis are a largely unaddressed driver of CKD progression in patients with T2D. MR overactivation can trigger the production of proinflammatory and profibrotic proteins, which may lead to irrevocable kidney damage.1-7

Inflammation and fibrosis in the kidneys can lead to albuminuria and a decline in kidney function8

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Learn more about the kidney damage that can occur when inflammation and fibrosis are left largely unaddressed1,2

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CKD: chronic kidney disease; MR: mineralocorticoid receptor; T2D: type 2 diabetes.


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  • Alicic RZ, et al. Clin J Am Soc Nephrol. 2017;12(12):2032–2045.
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  • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int Suppl. 2013;3(1):1–150.
  • Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. Kidney Int. 2020;98(4S):S1–S115.
  • American Diabetes Association. Diabetes Care. 2021;44(suppl 1):S1–S232.
  • Thomas MC, et al. Nat Rev Dis Primers. 2015;1. doi:10.1038/nrdp.2015.18.